MyBioSource.com's CEBPB Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The CEBPB Antibody was generated using C/EBP-beta, CEBPB, NFIL6, and TCF5 as the antigen and it reacts with Human, and Mouse.
Description
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. Isoform 3:acts as a dominant negative through heterodimerization with isoform 2.Akira S., EMBO J. 9:1897-1906(1990).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Deloukas P., Nature 414:865-871(2001)